JAK2V617F mutation is ubiquitously present in splanchnic vein thrombosis accompanying myeloproliferative syndromes
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چکیده
منابع مشابه
Role of the JAK2 mutation in the diagnosis of chronic myeloproliferative disorders in splanchnic vein thrombosis.
The diagnosis of an underlying chronic myeloproliferative disorder (CMPD) is often problematic in patients with primary extrahepatic portal vein obstruction (EHPVO) or Budd-Chiari syndrome (BCS); indeed, conventional clinical and hematological parameters usually yield insufficient information. To assess the diagnostic contribution of the gain-of-function mutation V617F of the JAK2 gene, 93 pati...
متن کاملSplanchnic vein thrombosis
Splanchnic vein thrombosis (SVT) – including mesenteric, portal, splenic and supra-hepatic veins thrombosis – is an underdiagnosed disease, with heterogeneous clinical presentations and a non-negligible rate of incidental findings. The main risk factors include abdominal diseases or interventions (e.g. infections, cirrhosis, abdominal cancer or surgical procedures), haematological disorders (ma...
متن کاملLatent Myeloproliferative Neoplasm as a Cause of Idiopathic Splanchnic Vein Thrombosis: The Role of JAK2V617F Mutation and Bone Marrow Biopsy Evaluation
Abbreviations: MPN: Myeloproliferative Neoplasms; PV: Polycythemia Vera; ET: Essential Thrombocythemia; PMF: Primary Myelofibrosis; CBC: Complete Blood Count; SVT: Splanchnic Veins Thrombosis; PVT: Portal Vein Thrombosis; BCS: Budd Chiari Syndrome; AST: Aspartate Amino Transferase; ALT: Alanine Aminotransferase; WBC: White Blood Cell count; CT: Computed Tomography; Ig: Immunoglobulin; ADP: Aden...
متن کاملSplanchnic vein thrombosis in myeloproliferative neoplasms: risk factors for recurrences in a cohort of 181 patients
We retrospectively studied 181 patients with polycythaemia vera (n=67), essential thrombocythaemia (n=67) or primary myelofibrosis (n=47), who presented a first episode of splanchnic vein thrombosis (SVT). Budd-Chiari syndrome (BCS) and portal vein thrombosis were diagnosed in 31 (17.1%) and 109 (60.3%) patients, respectively; isolated thrombosis of the mesenteric or splenic veins was detected ...
متن کاملSplanchnic vein thrombosis in myeloproliferative neoplasms: pathophysiology and molecular mechanisms of disease.
Myeloproliferative neoplasms (MPNs) are the most common underlying prothrombotic disorder found in patients with splanchnic vein thrombosis (SVT). Clinical risk factors for MPN-associated SVTs include younger age, female sex, concomitant hypercoagulable disorders, and the JAK2 V617F mutation. These risk factors are distinct from those associated with arterial or deep venous thrombosis (DVT) in ...
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ژورنال
عنوان ژورنال: Alimentary Pharmacology & Therapeutics
سال: 2011
ISSN: 0269-2813
DOI: 10.1111/j.1365-2036.2011.04670.x